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KMID : 0605620170240010001
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Journal of Korean Society of Biological Psychiatry
2017 Volume.24 No. 1 p.1 ~ p.9
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Animal Models of Demyelination and 1H-Magnetic Resonance Spectroscopy
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Cho Han-Byul
Lee Su-Ji
Park Shin-Won
Kang Il-Hyang
Ma Ji-Young
Jeong Hyeon-Seok
Kim Ji-Eun
Yoon Su-Jung
Lyoo In-Kyoon
Lim Soo-Mee
Kim Jung-Yoon
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Abstract
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The proton magnetic resonance spectroscopy (1H-MRS) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler’s murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.
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KEYWORD
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Proton magnetic resonance spectroscopy, Demyelination, Animal models
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